N-Aryl-3-mercaptosuccinimides as Antivirulence Agents TargetingPseudomonas aeruginosaElastase andClostridiumCollagenases
نویسندگان
چکیده
منابع مشابه
New 1-aryl-3-substituted propanol derivatives as antimalarial agents.
This paper describes the synthesis and in vitro antimalarial activity against a P. falciparum 3D7 strain of some new 1-aryl-3-substituted propanol derivatives. Twelve of the tested compounds showed an IC(50) lower than 1 microM. These compounds were also tested for cytotoxicity in murine J774 macrophages. The most active compounds were evaluated for in vivo activity against P. berghei in a 4-da...
متن کاملDiscovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer
A new chemical series of antiproliferative compounds was identified via high-throughput screening on DU-145 human prostate carcinoma cell line (hit compound potency - 5.7 microM). Exploration of the two peripheral diversity vectors of the hit molecule in a hit-targeted library and testing of the resulting compounds led to SAR generalizations and identification of the 'best' pharmacophoric moiet...
متن کاملQuorum Quenching Agents: Resources for Antivirulence Therapy
The continuing emergence of antibiotic-resistant pathogens is a concern to human health and highlights the urgent need for the development of alternative therapeutic strategies. Quorum sensing (QS) regulates virulence in many bacterial pathogens, and thus, is a promising target for antivirulence therapy which may inhibit virulence instead of cell growth and division. This means that there is li...
متن کاملTungstophosphoric acid embedded magnetic chitosan as a green catalyst for the synthesis of N-cyclohexyl-3-aryl quinoxaline-2-amines
In the present study, a novel catalyst was well designed by incorporating the tungstophosphoric acid into the magnetic chitosan, as highly stable composite, in which the iron oxides were used the strong super-magnetic core. The prepared composite was characterized by several methods, including FTIR, XRD, SEM, TEM and EDS and its catalytic activity was examined in a facile, green and highly effi...
متن کاملTungstophosphoric acid embedded magnetic chitosan as a green catalyst for the synthesis of N-cyclohexyl-3-aryl quinoxaline-2-amines
In the present study, a novel catalyst was well designed by incorporating the tungstophosphoric acid into the magnetic chitosan, as highly stable composite, in which the iron oxides were used the strong super-magnetic core. The prepared composite was characterized by several methods, including FTIR, XRD, SEM, TEM and EDS and its catalytic activity was examined in a facile, green and highly effi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2020
ISSN: 0022-2623,1520-4804
DOI: 10.1021/acs.jmedchem.0c00584